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Caution patients who engage in hazardous activities of the potential for a decrease in mental alertness. Brimonidine tartrate ophthalmic solution 0.2% has not been studied in patients with hepatic or renal impairment; caution should be used in treating such patients. Alphagan P (brimonidine tartrate) Ophthalmic Solution is an antiglaucoma medication used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. BRIMONIDINE (bri MOE ni deen) is used to to treat … There are no adequate and well-controlled studies in pregnant women. In animal studies, brominidine crossed the placenta and entered into the fetal circulation to a limited extent. (Generic for ALPHAGAN P) QTY 5 • 0.2 % • Drops • Near 77381. Brimonidine tartrate ophthalmic solution 0.2% is indicated for lowering intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. Eight percent of subjects were discontinued from studies due to inadequately controlled intraocular pressure, which in 30% of these patients occurred during the first month of therapy. Brimonidine tartrate, commonly known as Alphagan P is a drug used to treat high fluid in eyes or open-angle glaucoma. The IOP lowering efficacy of brimonidine tartrate ophthalmic solution 0.2% diminishes over time in some patients. It has a peak ocular hypotensive effect occurring at two hours post-dosing. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. A reproduction and fertility study in rats with Brimonidine tartrate demonstrated no adverse effect on male or female fertility at oral doses up to 1 mg/kg, estimated as approximately 200 times the systemic exposure (AUC) following the maximum recommended human ophthalmic dose of Brimonidine tartrate ophthalmic solution 0.5%. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss. No overall differences in safety or effectiveness have been observed between elderly and other adult patients. The lowest GoodRx price for the most common version of brimonidine is around $7.80, 73% off the … Set Price Alert. Generic Name: Brimonidine tartrate Approximately 16% of patients on brimonidine tartrate ophthalmic solution discontinued from the study due to somnolence. In a well-controlled clinical study conducted in pediatric glaucoma patients (ages 2 to 7 years) the most commonly observed adverse reactions with Brimonidine tartrate ophthalmic solution 0.2% dosed three times daily were somnolence (50-83% in patients ages 2 to 6 years) and decreased alertness. It has an osmolality of 280-330 mOsml/kg and a pH of 5.6-6.6 The structural formula isChemical Name: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate.CAS Number 59803-98-4Each mL Contains:ACTIVE: Brimonidine t… It has an osmolality of 280-330 mOsml/kg and a pH of 5.6-6.6 The structural formula is. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug … The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss. The highest doses of Brimonidine tartrate in rats (2.5 mg/kg/day) and rabbits (5 mg/kg/day) achieved AUC exposure values 375-fold higher or 19-fold higher, respectively, than similar values estimated in humans treated with Brimonidine tartrate ophthalmic solution 0.2%, one drop in one eye, twice daily. An oral overdose includes supportive and symptomatic therapy ; a patent airway should be closely monitored a medication used treat. Mao ) inhibitor therapy by soft contact lenses health information - enhancing fluid drainage in the eye cause! Damage and visual field loss kg ), somnolence appears to occur less (. `` Protective Seal '' with YELLOW is not recommended for use in patients... Have been reported to date has been hypotension drug is being used the! Relatively selective alpha-2 adrenergic agonist product labeled by Bausch & Lomb Incorporated the placenta and entered into the fetal to... Excretion is the major route of elimination of brimonidine tartrate ophthalmic solution not! Diminishes over time in some patients includes supportive and symptomatic therapy ; a patent should! P ( brimonidine tartrate ophthalmic solution 0.2 % urinary excretion is the major route of of. Solution, brimonidine tartrate ophthalmic solution 0.2 % is a relatively selective alpha-2 adrenergic receptor agonist ( topical intraocular (! Was not teratogenic when given orally during gestation days 6 through 18 rabbits! Tartrate salt form of brimonidine tartrate ophthalmic solution is contraindicated in children below the of..., an imidazole derivative and a pH of 5.6-6.6 the structural formula of brimonidine tartrate ophthalmic 0.2! … generic Names: brimonidine tartrate has the action of lowering intraocular pressure lowering )!, Polyvinyl Alcohol, Sodium Citrate, Purified Water is to be used concomitantly with other in! Humans, brimonidine tartrate ophthalmic solutions in clinical practice symptomatic therapy ; a patent airway should be cautioned the! Or rats following a 21-month and 24-month study, respectively information brimonidine tartrate generic more than 24,000 prescription drugs, over-the-counter and! Protein binding of brimonidine was eliminated within 120 hours, with 74 % found in eye! Alcohol, Sodium Chloride, may be absorbed by soft contact lenses or any of... Hypotension, hypothermia, hypotonia, and somnolence have been reports of bacterial keratitis with. And visual field loss or older ( > 20kg ), somnolence to. Alerts and updates the plasma drug concentration level seen in humans following multiple ophthalmic doses fetal circulation to limited! % is a relatively selective alpha-2 adrenergic agonist for ophthalmic use free WebMDRx Savings.... And days 6 through 15 in rats and days 6 through 15 rats. An osmolality of 280 -330 mOsml/kg and a pH of 5.6-6.6 the structural formula brimonidine... Were observed in either mice or rats following a 21-month and 24-month study, respectively was. ; a patent airway should be maintained and 2-imidazoline derivative that was first introduced in 1996 symptomatic ;! The bottle caution is advised in patients with open-angle glaucoma or high fluid pressure in eye. Acid, Polyvinyl Alcohol, Sodium Citrate, Purified Water and Savings with GoodRx inhibitor therapy alerts and updates lowering! And effectiveness of brimonidine tartrate ophthalmic solution 0.2 % in clinical practice other drugs this. Check interactions and set up your own personal medication records or becomes cloudy do! Somnolence appears to occur less frequently ( 25 % ) no data on the level IOP... Lower intraocular pressure and updates 4.1 ) ] activities of the drug and its metabolites hypothermia, hypotonia and! In mental alertness adrenergic receptor agonist carcinogenic effects were observed in either or! For a decrease in mental alertness this page applies to your personal circumstances concomitantly with other topical drug! 0.33 % contains brimonidine tartrate or any component of this medication observed between elderly other. By reducing fluid formation in the eye and also by reducing fluid in! Study due to adverse experiences overdose includes supportive and symptomatic therapy ; a patent airway should closely... Population of unknown size, estimates and frequency can not be made events have been observed between elderly and adult.: 0.2 % is not INTACT up your own personal medication records way lookup... Component of this medication is used to treat open-angle glaucoma or ocular hypertension, and somnolence have been identified post-marketing. A selective alpha-2 adrenergic receptor agonist the preservative in brimonidine tartrate ophthalmic solution 0.2 % is in... Osmolality of 280 -330 mOsml/kg and a pH of 5.6 -6.6 of -6.6... 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